Education, Fellowships and Publications

Dr. Anna Di Nardo graduated with honors in 1986 from the University of Pavia School of Medicine ( Italy). She trained as a dermatologist and was Board certified in Dermatology at the University of Modena Medical school (Italy) in 1989. In 1994, she obtained her Ph.D. diploma in Immunology and Clinical Allergology from the Ministry of University and Scientific Research in Italy (mentor: Dr. Giannetti). She practiced Dermatology in Italy for 10 years at the University of Modena. Since 2008 she has been ECFMG certified and has held an unrestricted California medical license. She practices Dermatology at UCSD
August 1989 - December 1989: Department of Dermatology, Skin Pharmacology, Institute of Human Pharmacology, Schering A&G- Berlin, Germany Schering Fellowship
June 1992 - March 1993: Department of Dermatology, School of Medicine, University of California San Francisco, Skin Barrier, Fellowship (Mentor: Dr. Maibach)
August 2000 - January 2001: Department of Dermatology, School of Medicine, University of California San Francisco, Skin Barrier, Fellowship (Mentors: Dr. Holleran, Dr. Elias)
January 2001 - January 2006: Department of Medicine Dermatology section, School of Medicine, University of California San Diego, Antimicrobial Peptide Fellowship (mentor: Dr Gallo)

Selected Publications

Vaccinia Virus Binds to the Scavenger Receptor MARCO on the Surface of Keratinocytes
MacLeod DT, Nakatsuji T, Wang Z, di Nardo A, Gallo RL
J Invest Dermatol



Mast cells are key mediators of cathelicidin-initiated skin inflammation in rosacea
Muto Y, Wang Z, Vanderberghe M, Two A, Gallo RL, Di Nardo A
J Invest Dermatol


Commensal bacteria lipoteichoic acid increases skin mast cell antimicrobial activity against vaccinia viruses
Wang Z, MacLeod DT, Di Nardo A
J Immunol



Skin mast cells protect mice against vaccinia virus by triggering mast cell receptor S1PR2 and releasing antimicrobial peptides
Wang Z, Lai Y, Bernard JJ, Macleod DT, Cogen AL, Moss B, Di Nardo A
J Immunol


Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons
Gregorio J, Meller S, Conrad C, Di Nardo A, Homey B, Lauerma A, Arai N, Gallo RL, Digiovanni J, Gilliet M
J Exp Med


Immunotherapy for melanoma: current status and perspectives
Alexandrescu DT, Ichim TE, Riordan NH, Marincola FM, Di Nardo A, Kabigting FD, Dasanu CA
J Immunother


Activation of TLR2 by a small molecule produced by Staphylococcus epidermidis increases antimicrobial defense against bacterial skin infections
Lai Y, Cogen AL, Radek KA, Park HJ, Macleod DT, Leichtle A, Ryan AF, Di Nardo A, Gallo RL
J Invest Dermatol


Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury
Lai Y, Di Nardo A, Nakatsuji T, Leichtle A, Yang Y, Cogen AL, Wu ZR, Hooper LV, Schmidt RR, von Aulock S, Radek KA, Huang CM, Ryan AF, Gallo RL
Nat Med


Collagen synthesis is suppressed in dermal fibroblasts by the human antimicrobial peptide LL-37 Park HJ, Cho DH, Kim HJ, Lee JY, Cho BK, Bang SI, Song SY, Yamasaki K, Di Nardo A, Gallo RL
J Invest Dermatol


Mast cell cathelicidin antimicrobial peptide prevents invasive group A Streptococcus infection of the skin
Di Nardo A, Yamasaki K, Dorschner RA, Lai Y, Gallo RL
J Immunol


Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea Yamasaki K, Di Nardo A, Bardan A, Murakami M, Ohtake T, Coda A, Dorschner RA, Bonnart C, Descargues P, Hovnanian A, Morhenn VB, Gallo RL
Nat Med


Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on toll-like receptor 4, cd44, and md-2
Taylor KR, Yamasaki K, Radek KA, Di Nardo A, Goodarzi H, Golenbock D, Beutler B, Gallo RL
Journal of Biological Chemistry


Cathelicidin antimicrobial peptides block dendritic cell TLR4 activation and allergic contact sensitization
Di Nardo A, Braff MH, Taylor KR, Na C, Granstein RD, McInturff JE, Krutzik S, Modlin RL, Gallo RL
J Immunol


Augmentation of cutaneous immune responses by ATP gamma S: purinergic agonists define a novel class of immunologic adjuvants
Granstein RD, Ding W, Huang J, Holzer A, Gallo RL, Di Nardo A, Wagner JA
J Immunol


Structure-function relationships among human cathelicidin peptides: dissociation of antimicrobial properties from host immunostimulatory activities
Braff MH, Hawkins MA, Di Nardo A, Lopez-Garcia B, Howell MD, Wong C, Lin K, Streib JE, Dorschner R, Leung DY, Gallo RL
J Immunol


Keratinocytes Store the Antimicrobial Peptide Cathelicidin in Lamellar Bodies
Braff MH, Di Nardo A, Gallo RL
J Invest Dermatol


Cutting edge: mast cell antimicrobial activity is mediated by expression of cathelicidin antimicrobial peptide
Di Nardo A, Vitiello A, Gallo RL
J Immunol